Induction of macrophage antiprotozoal activity by monocyte chemotactic and activating factor.
نویسندگان
چکیده
To determine if monocyte chemotactic and activating factor (MCAF) induces intracellular antimicrobial activity, human monocyte-derived macrophages were treated with MCAF and challenged with Toxoplasma gondii and Leishmania donovani. Pretreatment with MCAF induced macrophages to inhibit protozoal replication by approximately 50%. These findings suggest a potential host defense role for MCAF in the inflammatory response to intracellular pathogens.
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ورودعنوان ژورنال:
- FEMS immunology and medical microbiology
دوره 14 1 شماره
صفحات -
تاریخ انتشار 1996